Treatment | Ribes fasciculatum (ethylacetate fraction) | physical function | reproductive function | physiological function | healthspan biomarkers | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded |
CID (PubChem) | | ChEMBL | | | | | pharyngeal pumping | | | | number of offspring | | | | heat stress resistance | | | | oxidative stress resistance | | | | osmotic stress resistance | | | | autofluorescence (age pigment / lipofuscin) | | | | ROS level | | | | activity / quantity / expression of SODs | | | | activity / quantity / expression of SODs | | | | mean lifespan | | | | maximum lifespan | | | | | | | | | |
Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | | | | | | |
125 µg/ml | whole life; start: egg stage | OP50 | NGM agar | | N2 (wild type) | 20°C | down | | no | A4 and A8 | down | | yes | | up | | | A4; stressor: 36°C; endpoint: survival | up | | | A7; stressor: 60 mM paraquat; endpoint: survival | none | | no | A3; stressor: 500 mM NaCl for 12 h; endpoint: survival | down | | no | A8; green fluorescence | down | | no | A4; pre-exposed to 30 mM paraquat for 3 h; measured via H2DCF-DA | up | | yes | A5; measured via formazan | | | | | up | 2.50 | no | | up | 4.76 | n.d. | | | | | | Jeon H, Cha DS (2016) Anti-aging properties of Ribes fasciculatum in Caenorhabditis elegans. Chin J Nat Med 14, 335-342. doi: 10.3724/SP.J.1009.2016.00335. | no |
250 µg/ml | whole life; start: egg stage | OP50 | NGM agar | | N2 (wild type) | 20°C | down | | yes | A4 and A8 | down | | yes | | up | | | A4; stressor: 36°C; endpoint: survival | up | | | A7; stressor: 60 mM paraquat; endpoint: survival | up | | yes | A3; stressor: 500 mM NaCl for 12 h; endpoint: survival | down | | yes | A8; green fluorescence | down | | yes | A4; pre-exposed to 30 mM paraquat for 3 h; measured via H2DCF-DA | up | | yes | A5; measured via formazan | | | | | up | 11.10 | yes | | up | 4.76 | n.d. | | | | | | Jeon H, Cha DS (2016) Anti-aging properties of Ribes fasciculatum in Caenorhabditis elegans. Chin J Nat Med 14, 335-342. doi: 10.3724/SP.J.1009.2016.00335. | no |
500 µg/ml | whole life; start: egg stage | OP50 | NGM agar | | N2 (wild type) | 20°C | down | | yes | A4 and A8 | down | -34.40 | yes | | up | | | A4; stressor: 36°C; endpoint: survival | up | | | A7; stressor: 60 mM paraquat; endpoint: survival | up | | yes | A3; stressor: 500 mM NaCl for 12 h; endpoint: survival | down | -66.10 | yes | A8; green fluorescence | down | -41.00 | yes | A4; pre-exposed to 30 mM paraquat for 3 h; measured via H2DCF-DA | up | | yes | A5; measured via formazan | | | | | up | 16.30 | yes | | up | 19.05 | n.d. | | | | | | Jeon H, Cha DS (2016) Anti-aging properties of Ribes fasciculatum in Caenorhabditis elegans. Chin J Nat Med 14, 335-342. doi: 10.3724/SP.J.1009.2016.00335. | no |
500 µg/ml | whole life; start: egg stage | OP50 | NGM agar | | CF1553 {muIs84 [(pAD76)sod-3p::GFP + rol-6(su1006)]} | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 33.30 | yes | A3; pre-exposed to 36°C for 2 h; measured via fluorescence | | | | | | | | | | | | | Jeon H, Cha DS (2016) Anti-aging properties of Ribes fasciculatum in Caenorhabditis elegans. Chin J Nat Med 14, 335-342. doi: 10.3724/SP.J.1009.2016.00335. | no |
500 µg/ml | whole life; start: egg stage | OP50 | NGM agar | | GR1307 [daf-16(mgDf50)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | down | -1.00 | no | | none | | n.d. | | | | | | Jeon H, Cha DS (2016) Anti-aging properties of Ribes fasciculatum in Caenorhabditis elegans. Chin J Nat Med 14, 335-342. doi: 10.3724/SP.J.1009.2016.00335. | no |
500 µg/ml | whole life; start: egg stage | OP50 | NGM agar | | VC199 [sir-2.1(ok434)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 1.90 | no | | none | | n.d. | | | | | | Jeon H, Cha DS (2016) Anti-aging properties of Ribes fasciculatum in Caenorhabditis elegans. Chin J Nat Med 14, 335-342. doi: 10.3724/SP.J.1009.2016.00335. | no |
125 µg/ml | whole life; start: egg stage | OP50 | NGM agar | | AM1 [osr-1(rm1)] | 20°C | | | | | | | | | | | | | | | | | up | | no | A3; stressor: 500 mM NaCl for 12 h; endpoint: survival | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Jeon H, Cha DS (2016) Anti-aging properties of Ribes fasciculatum in Caenorhabditis elegans. Chin J Nat Med 14, 335-342. doi: 10.3724/SP.J.1009.2016.00335. | no |
250 µg/ml | whole life; start: egg stage | OP50 | NGM agar | | AM1 [osr-1(rm1)] | 20°C | | | | | | | | | | | | | | | | | up | | no | A3; stressor: 500 mM NaCl for 12 h; endpoint: survival | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Jeon H, Cha DS (2016) Anti-aging properties of Ribes fasciculatum in Caenorhabditis elegans. Chin J Nat Med 14, 335-342. doi: 10.3724/SP.J.1009.2016.00335. | no |
500 µg/ml | whole life; start: egg stage | OP50 | NGM agar | | AM1 [osr-1(rm1)] | 20°C | | | | | | | | | | | | | | | | | up | | no | A3; stressor: 500 mM NaCl for 12 h; endpoint: survival | | | | | | | | | | | | | | | | | up | 1.50 | no | | up | 5.88 | n.d. | | | | | | Jeon H, Cha DS (2016) Anti-aging properties of Ribes fasciculatum in Caenorhabditis elegans. Chin J Nat Med 14, 335-342. doi: 10.3724/SP.J.1009.2016.00335. | no |
500 µg/ml | whole life; start: egg stage | OP50 | NGM agar | | DR1572 [daf-2(e1368)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | down | -2.20 | no | | none | | n.d. | | | | | | Jeon H, Cha DS (2016) Anti-aging properties of Ribes fasciculatum in Caenorhabditis elegans. Chin J Nat Med 14, 335-342. doi: 10.3724/SP.J.1009.2016.00335. | no |
500 µg/ml | whole life; start: egg stage | OP50 | NGM agar | | TJ1052 [age-1(hx546)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 0.2 | no | | none | | n.d. | | | | | | Jeon H, Cha DS (2016) Anti-aging properties of Ribes fasciculatum in Caenorhabditis elegans. Chin J Nat Med 14, 335-342. doi: 10.3724/SP.J.1009.2016.00335. | no |
500 µg/ml | whole life; start: egg stage | OP50 | NGM agar | | FK171 [mek-1(ks54)] | 20°C | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | up | 11.90 | yes | | up | 15.00 | n.d. | | | | | | Jeon H, Cha DS (2016) Anti-aging properties of Ribes fasciculatum in Caenorhabditis elegans. Chin J Nat Med 14, 335-342. doi: 10.3724/SP.J.1009.2016.00335. | no |