Compound ID 339 (prev - next)

Name: Trimethadione (5576) (edit)

23 entries:

Treatment	Trimethadione						physical function																reproductive function								lifespan												Reference
CID (PubChem)	5576	ChEMBL					pharyngeal total span				fast pharyngeal pumping span				locomotion on solid media				fast body movement span				reproductive total span				quantity of internal hatch				mean lifespan				survival at a given time point				maximum lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
4 mg/ml	whole life; start: parental generation	OP50	NGM agar		N2 (wild type)	20°C	up	17.80	yes		up	16.05	yes		up		yes	measured as body bends per minute in young adults	up	23.17	yes		down	-10.34	yes		down	-86.52	n.d.		up	47.00	yes						up	57.00	yes		Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262.
4 mg/ml	whole life; start: L4	OP50	NGM agar		N2 (wild type)	20°C																									up	24.00	yes						up	29.00	yes		Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262.
4 mg/ml	start: parental generation; stop: L4	OP50	NGM agar		N2 (wild type)	20°C																									down	-7.00	no						down	-10.00	no		Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262.
4 mg/ml	whole life; start: parental generation	Bacillus subtilis	NGM agar		N2 (wild type)	20°C																									up	39.00	yes						up	33.00	yes		Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262.
4 mg/ml	whole life; start: parental generation	OP50, UV-inactivated	NGM agar		N2 (wild type)	20°C																									up	41.00	yes						up	23.00	yes		Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262.
2 mg/ml	whole life; start: parental generation	OP50	NGM agar		DR26 [daf-16(m26)]	20°C																									up	16.00	yes						up	10.00	n.d.		Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262.
4 mg/ml	whole life; start: parental generation	OP50	NGM agar		CF1038 [daf-16(mu86)]	20°C																									up	21.00	yes						up	23.00	yes		Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262.
4 mg/ml	whole life; start: parental generation	OP50	NGM agar		CB1370 [daf-2(e1370)]	20°C																									up	9.00	yes						down	-5.00	no		Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262.
4 mg/ml	whole life; start: parental generation	OP50	NGM agar		unknown strain [unc-31(e928)]	20°C																									up	24.00	yes						down	-1.00	no		Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262.
4 mg/ml	whole life; start: parental generation	OP50	NGM agar		CB246 [unc-64(e246)]	20°C																									up	24.00	yes						up	1.00	no		Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262.
4 mg/ml	whole life; start: parental generation	OP50	NGM agar		unknown strain [aex-3(ad418)]	20°C																									up	35.00	yes						up	18.00	yes		Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262.
4 mg/ml	whole life; start: parental generation	OP50	NGM agar		PR678 [tax-4(p678)]	20°C																									up	36.00	yes						up	12.00	yes		Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262.
4 mg/ml	whole life; start: parental generation	OP50	NGM agar		PR802 [osm-3(p802)]	20°C																									up	17.00	yes						up	2.00	no		Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262.
4 mg/ml	whole life; start: parental generation	OP50	NGM agar		DA465 [eat-2(ad465)]	20°C																									up	42.00	yes						up	50.00	yes		Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science. 307, 258-262.
5 mM (UV-treated trimethadione)	whole life; start: L4	OP50, UV-inactivated	NGM agar	FUDR; ampicillin	N2 (wild type)	20°C																													none			A7					Choi H, Schneider H, Klum S, Chandler-Brown D, Kaeberlein M, Shamieh L (2013) UV-photoconversion of ethosuximide from a longevity-promoting compound to a potent toxin. PLoS One 8, e82543.
10 mM (UV-treated trimethadione)	whole life; start: L4	OP50, UV-inactivated	NGM agar	FUDR; ampicillin	N2 (wild type)	20°C																													none			A7					Choi H, Schneider H, Klum S, Chandler-Brown D, Kaeberlein M, Shamieh L (2013) UV-photoconversion of ethosuximide from a longevity-promoting compound to a potent toxin. PLoS One 8, e82543.
50 mM (UV-treated trimethadione)	whole life; start: L4	OP50, UV-inactivated	NGM agar	FUDR; ampicillin	N2 (wild type)	20°C																													none			A7					Choi H, Schneider H, Klum S, Chandler-Brown D, Kaeberlein M, Shamieh L (2013) UV-photoconversion of ethosuximide from a longevity-promoting compound to a potent toxin. PLoS One 8, e82543.
5 mM	whole life; start: L4	OP50, UV-inactivated	NGM agar	FUDR; ampicillin	N2 (wild type)	20°C																													none			A7					Choi H, Schneider H, Klum S, Chandler-Brown D, Kaeberlein M, Shamieh L (2013) UV-photoconversion of ethosuximide from a longevity-promoting compound to a potent toxin. PLoS One 8, e82543.
10 mM	whole life; start: L4	OP50, UV-inactivated	NGM agar	FUDR; ampicillin	N2 (wild type)	20°C																													none			A7					Choi H, Schneider H, Klum S, Chandler-Brown D, Kaeberlein M, Shamieh L (2013) UV-photoconversion of ethosuximide from a longevity-promoting compound to a potent toxin. PLoS One 8, e82543.
50 mM	whole life; start: L4	OP50, UV-inactivated	NGM agar	FUDR; ampicillin	N2 (wild type)	20°C																													none			A7					Choi H, Schneider H, Klum S, Chandler-Brown D, Kaeberlein M, Shamieh L (2013) UV-photoconversion of ethosuximide from a longevity-promoting compound to a potent toxin. PLoS One 8, e82543.