Compound ID 346 (prev - next)

Name: Urolithin A (5488186) (edit)

40 entries:

Treatment	Urolithin A						physical function								reproductive function								physiological function				healthspan biomarkers																																lifespan				Transcriptome	Reference
CID (PubChem)	5488186	ChEMBL					pharyngeal pumping				locomotion on solid media				number of offspring				speed of larval development				oxidative stress resistance				ROS level				ATP level				oxygen consumption rate (OCR)				mitochondrial content/quality				activity / quantity / expression of HSPs				level of autophagy				activity / quantity / expression of GSTs				muscle integrity				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
10 µM	whole life; start: egg stage	OP50	NGM agar		N2 (wild type)	20°C																																																					up	24	yes			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
30 µM	whole life; start: egg stage	OP50	NGM agar		N2 (wild type)	20°C																																																					up	40,7	yes			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	OP50	NGM agar		N2 (wild type)	20°C	up		yes	A7 & A14; unchanged pumping at A1	up		yes	A3, A5, A8; unchanged mobility at A1	up		yes		none		no		up	12,3	yes	A8; percentage change at A1: 14.3; stressor: 4 mM paraquat; endpoint: mean survival	none		no		down		yes	A1; no significant differences at A8	down		yes	A1; no significant changes after exposure to 10 µM FCCP or at A8																	up		n.d.	A1 & A8	up	45,4	yes		A1: upregulation of bec-1, vps-34, rheb-1, pink-1, sqst-1, skn-1 and downregulation of fzo-1, opa-1, phi-37, mev-1, mrps-5 ; A8: upregulation of pink-1, cco-1, phi-37, mev-1, sdha-1	Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: A1	OP50, UV-inactivated	NGM agar		N2 (wild type)	20°C																																																					up	24	yes			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	start: egg stage; stop: L4	OP50	NGM agar		N2 (wild type)	20°C																																																					up	5,4	no			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: A1	OP50	NGM agar		N2 (wild type)	20°C																																																					up	37,5	yes			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: A4	OP50	NGM agar		N2 (wild type)	20°C																																																					up	31,7	yes			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: A8	OP50	NGM agar		N2 (wild type)	20°C																																																					up	19,3	yes			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	start: A1; stop: A4	OP50	NGM agar		N2 (wild type)	20°C																																																					up	25,6	yes			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	OP50	NGM agar		CF1038 [daf-16(mu86)]	20°C																																																					up	34,5	yes			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	OP50	NGM agar		DA465 [eat-2(ad465)]	20°C																																																					up	36,1	yes			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	OP50	NGM agar		RB754 [aak-2(ok524)]	20°C																																																					up	7,8	variable			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	OP50	NGM agar		TK22 [mev-1(kn1)]	20°C																																																					up	6,5	variable			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3)	NGM agar		N2 (wild type)	20°C					up		yes	A8; unchanged mobility at A1																					down		yes	A1; no significant changes after exposure to FCCP																					up	20,6	yes			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3) with RNAi-vector against bec-1	NGM agar		N2 (wild type)	20°C					down		yes	A8; unchanged mobility at A1																																													up	8,3	no			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3) with RNAi-vector against vps-34	NGM agar		N2 (wild type)	20°C																																																					up	5,2	no			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3) with RNAi-vector against pink-1	NGM agar		N2 (wild type)	20°C					down		yes	A8; unchanged mobility at A1																					none		no	A1; in presence and absence of 10 µM FCCP																					up	4,9	no			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3) with RNAi-vector against dct-1	NGM agar		N2 (wild type)	20°C																																																					down	-0,5	no			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3) with RNAi-vector against sqst-1	NGM agar		N2 (wild type)	20°C																																																					down	-1,7	no			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3) with RNAi-vector against skn-1	NGM agar		N2 (wild type)	20°C																																																					down	-7,4	variable			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: A1	OP50	NGM agar	N-acetylcysteine	N2 (wild type)	20°C																																																					up	33,5	yes			Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	OP50	NGM agar		CL2070 {dvIs70 [hsp-16.2p::GFP + rol-6(su1006)]}	20°C																																					none		no	Activity of hsp-16.2-promotor; measured via fluorescence																		Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	OP50	NGM agar		CL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}	20°C																																													none		no	Activity of gst-4-promotor; measured via fluorescence										Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	OP50	NGM agar		SJ4005 {zcIs4 [hsp-4::GFP]}	20°C																																					none		no	hsp-4 expression; measured via fluorescence																		Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	OP50	NGM agar		SJ4100 {zcIs13 [hsp-6::GFP]}	20°C																																					none		no	hsp-6 expression; measured via fluorescence																		Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	OP50	NGM agar		SJ4143 {zcIs17 [ges-1::GFP(mit)]}	20°C																																	variable		yes	content and size decreased at A1; content increased at A8																						Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	OP50	NGM agar		SJ4103 {zcIs14 [myo-3::GFP(mit)]}	20°C																																	down		yes	content & size decreased at A1; no significant changes at A8																						Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3)	NGM agar		SJ4103 {zcIs14 [myo-3::GFP(mit)]}	20°C																																	down		yes	content decreased at A1																						Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3)	NGM agar		SJ4143 {zcIs17 [ges-1::GFP(mit)]}	20°C																																	down		yes	content decreased at A1																						Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3) with RNAi-vector against bec-1	NGM agar		SJ4103 {zcIs14 [myo-3::GFP(mit)]}	20°C																																	up		no	content not significantly increased at A1																						Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3) with RNAi-vector against bec-1	NGM agar		SJ4143 {zcIs17 [ges-1::GFP(mit)]}	20°C																																	down		no	content not significantly decreased at A1																						Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3) with RNAi-vector against pink-1	NGM agar		SJ4103 {zcIs14 [myo-3::GFP(mit)]}	20°C																																	up		no	content not significantly increased at A1																						Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3) with RNAi-vector against pink-1	NGM agar		SJ4143 {zcIs17 [ges-1::GFP(mit)]}	20°C																																	down		no	content not significantly decreased at A1																						Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3) with RNAi-vector against dct-1	NGM agar		SJ4103 {zcIs14 [myo-3::GFP(mit)]}	20°C																																	down		no	content at A1																						Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3) with RNAi-vector against sqst-1	NGM agar		SJ4103 {zcIs14 [myo-3::GFP(mit)]}	20°C																																	down		no	content at A1																						Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	HT115 (DE3) with RNAi-vector against sqst-1	NGM agar		VC1024 [pdr-1 (gk448)]	20°C																													down		no	A1; in presence and absence of 10 µM FCCP																										Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
50 µM	whole life; start: egg stage	OP50	NGM agar		DA2123 {adls2122 [lgg-1p::GFP::lgg-1 + rol-6(su1006)]}	20°C																																									up		yes	A2														Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., ... & Aebischer, P. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.