Compound ID 359 (prev - next)

Name: Wisconsin Ginseng extract from Panax quinquefolius (edit)

7 entries:

Treatment	Wisconsin Ginseng extract from Panax quinquefolius						physical function												healthspan biomarkers				lifespan								Reference
CID (PubChem)		ChEMBL					pharyngeal pumping				locomotion on solid media				locomotion on solid media				muscle integrity				median lifespan				mean lifespan
Concentration	Exposure time	Food	Growth medium	Special additives	C. elegans strain	Temperature	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes	Change compared to control	Percentual change compared to control	p < 0.05	notes
100 µg/ml	whole life; start: L1	OP50	NGM agar		PD4251 {dpy-20(e1282); ccIs4251 [(pSAK2) myo-3p::GFP::LacZ::NLS + (pSAK4) myo-3p::mitochondrial GFP + dpy-20(+)]}	20°C													up	22.34	yes	age-associated muscle cellular deterioration measured by fluorescence; significant changes only in A15, not in A4, A7, and A10; Electron microscopy shows ultrastructural rejuvination of body wall muscle cells in A11	up	13.33	n.d.		up		no	only small differences are recognizable compared to control	Cao Z, Wu Y, Curry K, Wu Z, Christen Y, Luo Y (2007) Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 62, 1337-1345.
100 µg/ml	whole life; start: L1	OP50	NGM agar		N2 (wild type)	20°C	up		yes	A14; unchanged in A5, A8 and A11	up		yes	A3-A15; Fraction of worms moving sinusoidal after prodding or spontaniously; significant changes in A9, A11, and A13	up		yes	Significantly increased in A14; slightly increased (not significant) in A5 and A11; slightly decreased (not significant) in A8; measured by counting body bends													Cao Z, Wu Y, Curry K, Wu Z, Christen Y, Luo Y (2007) Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 62, 1337-1345.
10 µg/ml	whole life; start: L1	OP50	NGM agar		N2 (wild type)	20°C					up		n.d.	A3-A15; Fraction of worms moving sinusoidal after prodding or spontaniously																	Cao Z, Wu Y, Curry K, Wu Z, Christen Y, Luo Y (2007) Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 62, 1337-1345.
500 µg/ml	whole life; start: L1	OP50	NGM agar		N2 (wild type)	20°C					up		n.d.	A3-A15; Fraction of worms moving sinusoidal after prodding or spontaniously																	Cao Z, Wu Y, Curry K, Wu Z, Christen Y, Luo Y (2007) Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci 62, 1337-1345.