| Treatment | Fermented rice with Lactobacillus kefiranofaciens; dextrin included | physical function | physiological function | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | ChEMBL | locomotion on solid media | heat stress resistance | mean lifespan | ||||||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | ||||||
| 5 mg/ml | whole life; start: A1 | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | up | no | A3, A6, A9 | none | no | A1; stressor: 35°C for 10h or 4h, resp.; endpoint: survival and motility | up | no | Sugawara T, Furuhashi T, Shibata K, Abe M, Kikuchi K, Arai M, Sakamoto K (2019) Fermented product of rice with Lactobacillus kefiranofaciens induces anti-aging effects and heat stress tolerance in nematodes via DAF-16. Biosci Biotechnol Biochem 83, 1484-1489. | no | ||||||||
| 0.1 mg/ml | whole life; start: A1 | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | up | no | A3, A6, A9 | Sugawara T, Furuhashi T, Shibata K, Abe M, Kikuchi K, Arai M, Sakamoto K (2019) Fermented product of rice with Lactobacillus kefiranofaciens induces anti-aging effects and heat stress tolerance in nematodes via DAF-16. Biosci Biotechnol Biochem 83, 1484-1489. | no | |||||||||||||
| 0.5 mg/ml | whole life; start: A1 | OP50 | NGM agar | FUdR | N2 (wild type) | 20°C | up | yes | A9; no significant changes at A3 & A6 | Sugawara T, Furuhashi T, Shibata K, Abe M, Kikuchi K, Arai M, Sakamoto K (2019) Fermented product of rice with Lactobacillus kefiranofaciens induces anti-aging effects and heat stress tolerance in nematodes via DAF-16. Biosci Biotechnol Biochem 83, 1484-1489. | no | |||||||||||||
| 5 mg/ml | whole life; start: A1 | OP50 | NGM agar | FUdR | GR1307 [daf-16(mgDf50)] | 20°C | none | no | A1; stressor: 35°C for 4h; endpoint: recovery of motility | none | no | Sugawara T, Furuhashi T, Shibata K, Abe M, Kikuchi K, Arai M, Sakamoto K (2019) Fermented product of rice with Lactobacillus kefiranofaciens induces anti-aging effects and heat stress tolerance in nematodes via DAF-16. Biosci Biotechnol Biochem 83, 1484-1489. | no | |||||||||||