| Treatment | Ginkgolide A | physical function | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | ChEMBL | locomotion on solid media | ||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | change compared to control | percentage change compared to control | significant (p < 0.05) | notes | ||||||
| 25 μM | whole life; start: egg stage | OP50 | NGM agar | CL4176 {smg-1(cc546); dvIs27 [myo-3p::A-Beta (1-42)::let-851 3'UTR) + rol-6(su1006)]} | 16°C | up | yes | A1; temperature upshift to 25°C for 24h prior measurement; paralysis assay | DanQing L, YuJie G, ChengPeng Z, HongZhi D, Yi H, BiSheng H, Yan C (2020) N-butanol extract of Hedyotis diffusa protects transgenic Caenorhabditis elegans from Aβ-induced toxicity. Phytother Res 2020 Sep 13. | no | ||||||