Compound ID 4   (prev - next)

Name: 2-Ethylthio-8-methoxy-5-oxo-1-phenyl-1,5-dihydrobenzo[b][1,2,4]triazolo[1,5-g][1,6]naphthyridine-12-carbonitrile (compound 12a) (edit)

6 entries:
Treatment2-Ethylthio-8-methoxy-5-oxo-1-phenyl-1,5-dihydrobenzo[b][1,2,4]triazolo[1,5-g][1,6]naphthyridine-12-carbonitrile (compound 12a)physiological functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLheat stress resistanceoxidative stress resistanceconcentration of N(6)-Carboxymethyllysine (CML)ROS levelmean lifespan
Concentration12-carbonitrileFoodGrowth mediumSpecial additivesC. elegans strainTemperatureChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notesChange compared to controlPercentual change compared to controlp < 0.05notes
5 nMwhole life; start: unknownOP50NGM agarFUDRN2 (wild type)20°CnonenoA5; stressor: 35°C for 16h; endpoint: survivalupyesA5; stressor: 40 µM paraquat; endpoint: survivalnonenoA5; measured via ELISAnonenoA2; measured via H2DCF-DAup17.22yesMekheimer RA, Sayed AA, Ahmed EA, Sadek KU (2015) Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects. Arch Pharm (Weinheim) 348, 650-665.
50 nMwhole life; start: unknownOP50NGM agarFUDRN2 (wild type)20°CupnoA5; stressor: 35°C for 16h; endpoint: survivalupyesA5; stressor: 40 µM paraquat; endpoint: survivaldownnoA5; measured via ELISAdownyesA2; measured via H2DCF-DAup7.19yesMekheimer RA, Sayed AA, Ahmed EA, Sadek KU (2015) Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects. Arch Pharm (Weinheim) 348, 650-665.
500 nMwhole life; start: unknownOP50NGM agarFUDRN2 (wild type)20°CupyesA5; stressor: 35°C for 16h; endpoint: survivalnonenoA5; stressor: 40 µM paraquat; endpoint: survivaldownyesA5; measured via ELISAdownyesA2; measured via H2DCF-DAup0.43noMekheimer RA, Sayed AA, Ahmed EA, Sadek KU (2015) Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects. Arch Pharm (Weinheim) 348, 650-665.