| Treatment | 7-Isobutylamino-2-ethylthio-6-formyl-5-oxo-1-phenyl-1,5-dihydro-[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile (compound 4c) | physiological function | lifespan | Transcriptome | Proteome | Metabolome | Target | Reference | blinded | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CID (PubChem) | ChEMBL | oxidative stress resistance | mean lifespan | |||||||||||||||||
| Concentration | Exposure time | Food | Growth medium | Special additives | C. elegans strain | Temperature | Change compared to control | Percentual change compared to control | p < 0.05 | notes | Change compared to control | Percentual change compared to control | p < 0.05 | notes | ||||||
| 5 nM | whole life; start: unknown | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | none | no | A5; stressor: 40 µM paraquat; endpoint: survival | none | no | Mekheimer RA, Sayed AA, Ahmed EA, Sadek KU (2015) Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects. Arch Pharm (Weinheim) 348, 650-665. | ||||||||
| 50 nM | whole life; start: unknown | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | none | no | A5; stressor: 40 µM paraquat; endpoint: survival | none | no | Mekheimer RA, Sayed AA, Ahmed EA, Sadek KU (2015) Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects. Arch Pharm (Weinheim) 348, 650-665. | ||||||||
| 500 nM | whole life; start: unknown | OP50 | NGM agar | FUDR | N2 (wild type) | 20°C | none | no | A5; stressor: 40 µM paraquat; endpoint: survival | none | no | Mekheimer RA, Sayed AA, Ahmed EA, Sadek KU (2015) Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects. Arch Pharm (Weinheim) 348, 650-665. | ||||||||