Compound ID 412   (prev - next)

Name: phenformin (edit)

13 entries:
Treatmentphenforminphysical functionreproductive functionhealthspan biomarkerslifespanTranscriptomeProteomeMetabolomeTargetReferenceblinded
CID (PubChem)ChEMBLbody length / growth ratenumber of offspringvertex (progeny per day)activity / quantity / expression of GSTsmean lifespan
ConcentrationExposure timeFoodGrowth mediumSpecial additivesC. elegans strainTemperaturechange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)noteschange compared to controlpercentage change compared to controlsignificant (p < 0.05)notes
1.5 mMwhole life; start: L4OP50NGM agarFUDRN2 (wild type)20°Cup5.35yesA2; up-regulation of pAAK-2Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
3 mMwhole life; start: L4OP50NGM agarFUDRN2 (wild type)20°Cup20.66yesA2; up-regulation of pAAK-2Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
4.5 mMwhole life; start: L4OP50NGM agarFUDRN2 (wild type)20°Cup26.38yesA2; up-regulation of pAAK-2Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
4.5 mMwhole life; start: L4OP50NGM agarFUDRGA1001 [aak-2(ok524)]20°Cdown-15.48yesCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
4.5 mMwhole life; start: L4OP50NGM agarFUDREU31 [skn-1(zu135)/nT1 [unc-?(n754) let-?]]20°Cdown-3.21noCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
4.5 mMwhole life; start: L1OP50NGM agarCL2166 {dvIs19 [(pAF15)gst-4p::GFP::NLS]}20°CupyesL4; expression of gst-4; measured via fluorescenceCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
4.5 mMwhole life; start: L1OP50NGM agarGA1112 {aak-2(ok524); dvIs19 [pAF15 (gst-4::GFP::NLS)]}20°CnonenoL4; expression of gst-4; measured via fluorescenceCabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
1.5 mMwhole life; start: L1OP50NGM agarN2 (wild type)20°CdownyesL4downnodownyesday 2Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
3 mMwhole life; start: L1OP50NGM agarN2 (wild type)20°CdownyesL4downyesdownyesday 1-3Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no
4.5 mMwhole life; start: L1OP50NGM agarN2 (wild type)20°CdownyesL4downyesdownyesday 1-3Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153, 228-239. no